United States securities and exchange commission logo

                          August 14, 2023

       Balkrishan (Simba) Gill, Ph.D.
       Chief Executive Officer
       Evelo Biosciences, Inc.
       620 Memorial Drive
       Cambridge, Massachusetts 02139

                                                        Re: Evelo Biosciences,
Statement on Form S-3
                                                            Filed August 10,
                                                            File No. 333-273869

       Dear Balkrishan (Simba) Gill:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Joshua
Gorsky at 202-551-7836 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Peter N. Handrinos,