United States securities and exchange commission logo

                 August 26, 2021

       Daniel Char
       Secretary and General Counsel
       Evelo Biosciences, Inc.
       620 Memorial Drive
       Cambridge, Massachusetts 02139

                                                        Re: Evelo Biosciences,
Statement on Form S-3
                                                            Filed August 23,
                                                            File No. 333-259005

       Dear Mr. Char:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

              Please contact Michael Davis at 202-551-4385 or Joe McCann at
202-551-6262 with any


                 Division of Corporation Finance

                 Office of Life Sciences
       cc:                                              Peter N. Handrinos