United States securities and exchange commission logo August 14, 2023 Balkrishan (Simba) Gill, Ph.D. Chief Executive Officer Evelo Biosciences, Inc. 620 Memorial Drive Cambridge, Massachusetts 02139 Re: Evelo Biosciences, Inc. Registration Statement on Form S-3 Filed August 10, 2023 File No. 333-273869 Dear Balkrishan (Simba) Gill: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Joshua Gorsky at 202-551-7836 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Peter N. Handrinos, Esq.